Lebanese sources report that the IDF struck a villa near al-Barghalia, north of Tyre on the Mediterranean coast.
A video shows secondary explosions, suggesting ammunition was stored in the building.
The villa's owner is currently unknown.
Media linked to Hezbollah quickly claimed there were no casualties, but this information is still being verified.
This marks a change in IDF strategy, as previous strikes in this conflict had not targeted areas north of Tyre.